Maznyczka, A. M., Oldroyd, K. G., McCartney, P., McEntegart, M. and Berry, C. (2019) The potential use of the index of microcirculatory resistance to guide stratification of patients for adjunctive therapy in acute myocardial infarction. JACC: Cardiovascular Interventions, 12(10), pp. 951-966. (doi: 10.1016/j.jcin.2019.01.246) (PMID:31122353)
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Abstract
The goal of reperfusion therapies in ST-segment elevation myocardial infarction has evolved to include effective reperfusion of the microcirculation subtended by the culprit epicardial coronary artery. The index of microcirculatory resistance is measured using a pressure- and temperature-sensing coronary guidewire and quantifies microvascular dysfunction. The index of microcirculatory resistance is an independent predictor of microvascular obstruction, infarct size, and adverse clinical outcomes. It has the advantage of being immediately measurable in the catheterization laboratory, before the results of blood biomarkers or noninvasive imaging become available. This provides an opportunity for additional intervention that may alter outcomes. In this review, the authors provide a critical appraisal of the published research on the emerging role of the index of microcirculatory resistance as a tool to guide the stratification of patients for adjunctive therapeutic strategies in acute ST-segment elevation myocardial infarction.
Item Type: | Articles |
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Keywords: | ST-segment elevation myocardial, adjunctive therapy, index of microcirculatory resistance, infarction, microvascular obstruction, stratified medicine. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McEntegart, Dr Margaret and McCartney, Dr Peter and Oldroyd, Dr Keith and Berry, Professor Colin and Maznyczka, Dr Annette Marie |
Authors: | Maznyczka, A. M., Oldroyd, K. G., McCartney, P., McEntegart, M., and Berry, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | JACC: Cardiovascular Interventions |
Publisher: | Elsevier |
ISSN: | 1936-8798 |
ISSN (Online): | 1876-7605 |
Published Online: | 20 May 2019 |
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