Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Dunlop, M. G. et al. (2012) Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nature Genetics, 44(7), pp. 770-776. (doi: 10.1038/ng.2293) (PMID:22634755) (PMCID:PMC4747430)

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We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10−10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10−10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10−10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Item Type:Articles
Additional Information:Chiara Braconi is a member of the COIN Collaborative Group.
Glasgow Author(s) Enlighten ID:Braconi, Dr Chiara
Authors: Dunlop, M. G., Dobbins, S. E., Farrington, S. M., Jones, A. M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L.-Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y. P., Barclay, E., Prendergast, J., Cazier, J.-B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L. G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Starr, J. M., Deary, I., Kirac, I., Kovacević, D., Aaltonen, L. A., Renkonen-Sinisalo, L., Mecklin, J.-P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D. J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M. A., Schumacher, F., Casey, G., Easton, D., Shah, M., Pharoah, P., Lindblom, A., Liu, T., Smith, C. G., West, H., Cheadle, J. P., Midgley, R., Kerr, D. J., Campbell, H., Tomlinson, I. P., Houlston, R. S., and Braconi, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nature Genetics
Publisher:Nature Publishing Group
ISSN (Online):1546-1718
Published Online:27 May 2012

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