Beradi, R. et al. (2006) Anemia may influence the outcome of patients undergoing neo-adjuvant treatment of rectal cancer. Annals of Oncology, 17(11), pp. 1661-1664. (doi: 10.1093/annonc/mdl285) (PMID:16968873)
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Abstract
Background: We hypothesized that anemia could represent one of the major factors influencing the outcome of patients undergoing neo-adjuvant treatment of rectal cancer. Patients and methods: This analysis included all the consecutive patients who underwent neo-adjuvant treatment (chemotherapy and/or radiotherapy) before surgery for rectal cancer in three oncology/radiotherapy departments from June 1996 to December 2003. Results: Three hundred and seventeen patients were eligible for our analysis. Median age at diagnosis was 64 years (range 26–88 years); male/female ratio was 184/133. Two hundred and eighty-five patients (89.9%) were diagnosed with adenocarcinoma, while 32/317 (10.1%) with mucinous adenocarcinoma. Neo-adjuvant treatments carried out were as follows: radiotherapy alone in 75/317 patients (23.7%), radiotherapy plus chemotherapy in 242/317 patients (76.3%). At univariate and multivariate analysis, only the hemoglobin (Hb) level (group 1: ≤12 g/dl versus group 2: >12 g/dl) resulted in a significant factor for disease-free survival. The role of the Hb level seemed to be confirmed further by the clinical downstaging obtained in ∼55% of patients in group 2, in comparison with 35% of the patients achieving a significant downstaging in group 1. Conclusion: Our results indicated that anemia could represent an important parameter able to influence the outcome in patients receiving neo-adjuvant treatment of rectal cancer.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Braconi, Dr Chiara |
| Authors: | Beradi, R., Braconi, C., Mantello, G., Scartozzi, M., Del Prete, S., Luppi, G., Martinelli, R., Fumagalli, M., Valeri, G., Bearzi, I., Marmovale, C., Grillö-Ruggieri, F., and Cascinu, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Annals of Oncology |
| Publisher: | Oxford University Press |
| ISSN: | 0923-7534 |
| ISSN (Online): | 1569-8041 |
| Published Online: | 12 September 2006 |
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