Kayhanian, H., Smyth, E. C. and Braconi, C. (2017) Emerging molecular targets and therapy for cholangiocarcinoma. World Journal of Gastrointestinal Oncology, 9(7), pp. 268-280. (doi: 10.4251/wjgo.v9.i7.268) (PMID:28808500) (PMCID:PMC5534395)
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Abstract
Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Braconi, Dr Chiara |
| Authors: | Kayhanian, H., Smyth, E. C., and Braconi, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | World Journal of Gastrointestinal Oncology |
| Publisher: | Baishideng Publishing Group |
| ISSN: | 1948-5204 |
| ISSN (Online): | 1948-5204 |
| Published Online: | 24 March 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in World Journal of Gastrointestinal Oncology 9(7): 268-280 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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