Emerging molecular targets and therapy for cholangiocarcinoma

Kayhanian, H., Smyth, E. C. and Braconi, C. (2017) Emerging molecular targets and therapy for cholangiocarcinoma. World Journal of Gastrointestinal Oncology, 9(7), pp. 268-280. (doi: 10.4251/wjgo.v9.i7.268) (PMID:28808500) (PMCID:PMC5534395)

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Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Braconi, Dr Chiara
Authors: Kayhanian, H., Smyth, E. C., and Braconi, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:World Journal of Gastrointestinal Oncology
Publisher:Baishideng Publishing Group
ISSN (Online):1948-5204
Published Online:24 March 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in World Journal of Gastrointestinal Oncology 9(7): 268-280
Publisher Policy:Reproduced under a Creative Commons License

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