Oligometastatic gastric cancer: an emerging clinical entity with distinct therapeutic implications

Salati, M., Valeri, N., Spallanzani, A., Braconi, C. and Cascinu, S. (2019) Oligometastatic gastric cancer: an emerging clinical entity with distinct therapeutic implications. European Journal of Surgical Oncology, 45(8), pp. 1479-1482. (doi: 10.1016/j.ejso.2018.11.006) (PMID:30448343)

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Abstract

Gastric cancer (GC) remains responsible for a high burden worldwide being the third leading cause of cancer-related mortality. Most of patients present at an advanced stage at diagnosis and are thus candidates to standard chemotherapy resulting in median survival of less than 1 year. Oligometastatic gastric cancer is an increasingly recognized clinical entity characterized by limited metastatic spread that has been showing to benefit from aggressive multimodality strategies encompassing chemotherapy and surgery. The ongoing RENAISSANCE/AIO-FLOT5 (NCT02578368) phase III trial is aimed at evaluating if perioperative chemotherapy with FLOT in combination with surgical resection of the primary tumour and metastases could become the new standard of care for oligometastatic GC. In the meantime, in addition to currently available clinical parameters, the emerging predictive/prognostic role of biomarkers such mismatch repair deficiency/microsatellite instability high status needs to be specifically addressed also in this subgroup of GC to assist in patient selection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Valeri, Dr Nicola and Braconi, Dr Chiara
Authors: Salati, M., Valeri, N., Spallanzani, A., Braconi, C., and Cascinu, S.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:European Journal of Surgical Oncology
Publisher:Elsevier
ISSN:0748-7983
ISSN (Online):1532-2157
Published Online:10 November 2018
Copyright Holders:Copyright © 2018 Elsevier Ltd.
First Published:First published in European Journal of Surgical Oncology 45(8): 1479-1482
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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