Validation and application of health utilities index in Chinese subjects with down syndrome

Mok, W. K. Y., Wong, W. H.-S., Mok, G. T. K., Chu, Y. W. Y., Ho, F. K.-W., Chow, C. B., Ip, P. and Chung, B. H.-Y. (2014) Validation and application of health utilities index in Chinese subjects with down syndrome. Health and Quality of Life Outcomes, 12, 144. (doi: 10.1186/s12955-014-0144-x) (PMID:25311245) (PMCID:PMC4207901)

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Abstract

Objectives: The objectives of the study were (1) to validate the Chinese version of Health Utilities Index (HUI-Ch); (2) to examine the Health-related Quality of Life (HRQoL) of Chinese subjects with Down syndrome (DS); and (3) to study the impact of chronic health conditions on HRQoL of Chinese with DS. Methods: The multiple choice questionnaire for scoring Health Utilities Index Mark 2 (HUI2) and Health Utilities Index Mark 3 (HUI3) was translated and validated. In addition to the HRQoL scores from HUI2 and HUI3, proxy-data on socio-demographics, and 10 common chronic health conditions for people with DS were collected and analyzed. Data analysis involves multiple imputation and multiple regression analysis to predict variations in HRQoL in relation to different factors. Lastly, a gradient interval was constructed on the number of chronic health conditions in relation to HRQoL. Results: HUI-Ch was validated according to standard guidelines. People with DS were found to have a lower HRQoL as compared to the general population, with the majority categorized as moderate or severe on the scale. Behavioral and hearing problems on HUI2, and hearing problems on HUI3 were found to be statistically significant predictors of a lower HRQoL score. A significant gradient relationship existed showing when the number of health problems increased, the HRQoL scores decreased. Conclusions: HUI-Ch is a valid instrument to assess HRQoL. It can have broad application in Chinese subjects with DS including the study of the impact of different chronic health conditions on their quality of life. The quantifiable nature of HUI-Ch will facilitate longitudinal study on the well-being of subjects with DS and evaluation of effectiveness of intervention programs in the near future.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ho, Dr Frederick
Authors: Mok, W. K. Y., Wong, W. H.-S., Mok, G. T. K., Chu, Y. W. Y., Ho, F. K.-W., Chow, C. B., Ip, P., and Chung, B. H.-Y.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:Health and Quality of Life Outcomes
Publisher:BioMed Central
ISSN:1477-7525
ISSN (Online):1477-7525
Copyright Holders:Copyright © 2014 Mok et al.
First Published:First published in Health and Quality of Life Outcomes 12: 144
Publisher Policy:Reproduced under a Creative Commons License

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