Refugia and anthelmintic resistance: concepts and challenges

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi: 10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

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Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in ‘refugia’, unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen and McIntyre, Dr Jennifer and Morrison, Dr Thomas and Laing, Dr Roz and Babayan, Dr Simon and Mable, Professor Barbara and Britton, Professor Collette and Matthews, Professor Louise and Prentice, Dr Jamie
Authors: Hodgkinson, J. E., Kaplan, R. M., Kenyon, F., Morgan, E. R., Park, A. W., Paterson, S., Babayan, S. A., Beesley, N. J., Britton, C., Chaudhry, U., Doyle, S. R., Ezenwa, V. O., Fenton, A., Howell, S. B., Laing, R., Mable, B. K., Matthews, L., McIntyre, J., Milne, C. E., Morrison, T. A., Prentice, J., Sargison, N. D., Williams, D. J.L., Wolstenholme, A. J., and Devaney, E.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:International Journal for Parasitology
ISSN (Online):2211-3207
Published Online:17 May 2019
Copyright Holders:Copyright © 2019 Elsevier Ltd.
First Published:First published in International Journal for Parasitology: Drugs and Drug Resistance 10:51-57
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
724091United States-UK partnering award:Co-infection and resistance (CORE)Eileen DevaneyBiotechnology and Biological Sciences Research Council (BBSRC)BB/N022386/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED