Mechanics of the tricuspid valve: from clinical diagnosis/treatment, in vivo and in vitro investigations, to patient-specific biomechanical modeling

Lee, C.-H. et al. (2019) Mechanics of the tricuspid valve: from clinical diagnosis/treatment, in vivo and in vitro investigations, to patient-specific biomechanical modeling. Bioengineering, 6(2), 47. (doi: 10.3390/bioengineering6020047) (PMID:31121881) (PMCID:PMC6630695)

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Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus, may lead to functional tricuspid regurgitation (FTR), where the valve is unable to prevent undesired backflow of blood from the right ventricle into the right atrium during systole. Various treatment options are currently available for FTR; however, research for the tricuspid heart valve, functional tricuspid regurgitation, and the relevant treatment methodologies are limited due to the pervasive expectation among cardiac surgeons and cardiologists that FTR will naturally regress after repair of left-sided heart valve lesions. Recent studies have focused on (i) understanding the function of the TV and the initiation or progression of FTR using both in-vivo and in-vitro methods, (ii) quantifying the biomechanical properties of the tricuspid valve apparatus as well as its surrounding heart tissue, and (iii) performing computational modeling of the TV to provide new insight into its biomechanical and physiological function. This review paper focuses on these advances and summarizes recent research relevant to the TV within the scope of FTR. Moreover, this review also provides future perspectives and extensions critical to enhancing the current understanding of the functioning and remodeling tricuspid valve in both the healthy and pathophysiological states.

Item Type:Articles
Additional Information:Support from the American Heart Association Scientist Development Grant (SDG) Award (16SDG27760143) is gratefully acknowledged. CHL was in part supported by the institutional start-up funds from the School of Aerospace and Mechanical Engineering (AME), the IBEST-OUHSC Funding for Interdisciplinary Research, and the research funding through the Faculty Investment Program from the Research Council at the University of Oklahoma (OU).
Glasgow Author(s) Enlighten ID:Aggarwal, Dr Ankush
Authors: Lee, C.-H., Laurence, D., Ross, C., Kramer, K., Babu, A. R., Johnson, E. L., Hsu, M.-C., Aggarwal, A., Mir, A., Burkhart, H. M., Towner, R. A., Baumwart, R., and Wu, Y.
College/School:College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Bioengineering
ISSN (Online):2306-5354
Published Online:22 May 2019
Copyright Holders:Copyright © 2019 by the authors
First Published:First published in Bioengineering 6(2):47
Publisher Policy:Reproduced under a Creative Commons license

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