Predictors of gait speed and its change over three years in community-dwelling older people

Pinter, D. et al. (2018) Predictors of gait speed and its change over three years in community-dwelling older people. Aging, 10(1), pp. 144-153. (doi: 10.18632/aging.101365) (PMID:29356686) (PMCID:PMC5811248)

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We aimed to assess whether and how changes in brain volume and increases in white matter hyperintensity (WMH) volume over three years predict gait speed and its change independently of demographics, vascular risk factors and physical status. We analyzed 443 individuals from the Lothian Birth Cohort 1936, at mean age 73 and 76 years. Gait speed at age 76 was predicted by age, grip strength and body mass index at mean age 73, three-year brain volume decrease and WMH volume increase, explaining 26.1% of variance. Decline in gait speed to age 76 was predicted by the same five variables explaining 40.9% of variance. In both analyses, grip strength and body mass index explained the most variance. A clinically significant decline in gait speed (≥ 0.1 m/s per year) occurred in 24.4%. These individuals had more structural brain changes. Brain volume and WMH changes were independent predictors of gait dysfunction and its three-year change, but the impact of malleable physical factors such as grip strength or body mass index was greater.

Item Type:Articles
Additional Information:DP receives funding from the Austrian Science Fund T 690-B23. LBC1936 data collection was supported by the Disconnected Mind project funded by Age UK. SJR and DAD are funded by the UK Medical Research Council (MRC); The brain imaging is part-funded by the Scottish Funding Council as part of the SINAPSE Collaboration ( The work was undertaken by the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Funding from the Biotechnology and Biological Sciences Research Council (BBSRC), MRC, the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease, ref no. 16 CVD 05, and the European Union Horizon 2020, PHC-03-15, project No 666881, ‘SVDs@Target’, is gratefully acknowledged.
Glasgow Author(s) Enlighten ID:Dickie, Dr David Alexander
Authors: Pinter, D., Ritchie, S. J., Gattringer, T., Bastin, M. E., Hernández, M. d. C. V., Corley, J., Maniega, S. M., Pattie, A., Dickie, D. A., Gow, A. J., Starr, J. M., Deary, I. J., Enzinger, C., Fazekas, F., and Wardlaw, J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Aging
Publisher:Impact Journals
ISSN (Online):1945-4589
Copyright Holders:Copyright © 2017 Pinter et al.
First Published:First published in Aging 10(1):144-153
Publisher Policy:Reproduced under a Creative Commons License

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