Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy

Sakpakdeejaroen, I., Somani, S., Mullin, M. and Dufès, C. (2020) Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy. Journal of Liposome Research, 30(2), pp. 174-181. (doi: 10.1080/08982104.2019.1614054) (PMID:31060409)

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Originally developed for the treatment of inflammatory disorders, the non-steroidal anti-inflammatory drug aspirin was shown to have a preventive effect against cancer in the past decades. Most importantly, recent studies suggested that it might also provide a therapeutic benefit in the treatment of cancer in vitro. However, this drug failed to specifically reach tumors at a therapeutic concentration following intravenous administration, thus resulting in lack of efficacy on tumors. In this work, we demonstrated that aspirin could be formulated in transferrin-bearing vesicles and that this tumor-targeted formulation could lead to an increase in the anti-proliferative efficacy of the drug in three cancer cell lines in vitro. The in vitro therapeutic efficacy of aspirin was significantly improved when formulated in transferrin-bearing vesicles, by about 2-fold compared to that of drug solution. These results are promising and support the optimization of this delivery system to further improve its potential as a therapeutic tool in combination with other anti-cancer therapies.

Item Type:Articles
Additional Information:This work was financially supported by a Thammasat University Scholarship to I.S. [scholarship number TU_9708]. S.S. is funded by a research grant from The Dunhill Medical Trust [grant number R463/0216].
Glasgow Author(s) Enlighten ID:Mullin, Mrs Margaret
Authors: Sakpakdeejaroen, I., Somani, S., Mullin, M., and Dufès, C.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Liposome Research
Publisher:Taylor & Francis
ISSN (Online):1532-2394
Published Online:05 June 2019

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