Michie, A.M. and Nakagawa, R. (2005) The link between PKC alpha regulation and cellular transformation. Immunology Letters, 96(2), pp. 155-162. (doi: 10.1016/j.imlet.2004.08.013)
Full text not currently available from Enlighten.
Abstract
Protein kinase Calpha (PKCalpha) is a serine/threonine protein kinase that has been implicated in the regulation of a variety of cellular functions such as proliferation, differentiation and apoptosis in response to a diverse range of stimuli. In order to execute these biological events PKCalpha activity is modulated by, and functionally interacts with, a number of proto-oncogenes, therefore it is perhaps unsurprising that dysregulation of PKCalpha is associated with a diverse range of cancers. Recently, PKCalpha has become a target for a number of anti-cancer therapies. The purpose of this review is to describe how PKCalpha regulates key biological events, to gain an insight into how PKCalpha-mediated cellular transformation may occur. In this way, it may be possible to design therapeutic tools to combat cancers specifically associated with PKCalpha dysfunction.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Michie, Professor Alison |
| Authors: | Michie, A.M., and Nakagawa, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Immunology Letters |
| ISSN: | 0165-2478 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric