The future of cardiovascular stents: bioresorbable and integrated biosensor technology

Hoare, D., Bussooa, A., Neale, S. , Mirzai, N. and Mercer, J. (2019) The future of cardiovascular stents: bioresorbable and integrated biosensor technology. Advanced Science, 6(20), 1900856. (doi: 10.1002/advs.201900856) (PMID:31637160) (PMCID:PMC6794628)

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Cardiovascular disease is the greatest cause of death worldwide. Atherosclerosis is the underlying pathology responsible for two thirds of these deaths. It is the age‐dependent process of “furring of the arteries.” In many scenarios the disease is caused by poor diet, high blood pressure, and genetic risk factors, and is exacerbated by obesity, diabetes, and sedentary lifestyle. Current pharmacological anti‐atherosclerotic modalities still fail to control the disease and improvements in clinical interventions are urgently required. Blocked atherosclerotic arteries are routinely treated in hospitals with an expandable metal stent. However, stented vessels are often silently re‐blocked by developing “in‐stent restenosis,” a wound response, in which the vessel's lumen renarrows by excess proliferation of vascular smooth muscle cells, termed hyperplasia. Herein, the current stent technology and the future of biosensing devices to overcome in‐stent restenosis are reviewed. Second, with advances in nanofabrication, new sensing methods and how researchers are investigating ways to integrate biosensors within stents are highlighted. The future of implantable medical devices in the context of the emerging “Internet of Things” and how this will significantly influence future biosensor technology for future generations are also discussed.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hoare, Mr Daniel and Neale, Dr Steven and Bussooa, Anubhav and Mercer, Dr John and Mirzai, Mr Nosrat
Authors: Hoare, D., Bussooa, A., Neale, S., Mirzai, N., and Mercer, J.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Advanced Science
ISSN (Online):2198-3844
Published Online:19 August 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Advanced Science 6(20):1900856
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
617771BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177RI CARDIOVASCULAR & MEDICAL SCIENCES
3013360Design and fabrication of a remote controlled wireless impedance sensing unit for a new cardiovascular medical device.John MercerChief Scientist Office (CSO)CGA/17/29CAMS - Cardiovascular Science