Rewards, perils and pitfalls of untangling spinal pain circuits

Graham, B. A. and Hughes, D. I. (2019) Rewards, perils and pitfalls of untangling spinal pain circuits. Current Opinion in Physiology, 11, pp. 35-41. (doi: 10.1016/j.cophys.2019.04.015)

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Pain is a complex perception that is fundamental to our daily survival. Under normal circumstances, it serves an important protective function to guard against tissue damage or alert the body to dangerous environments. Under pathological states, however, the perception of pain can become chronic, maladaptive, resistant to treatment, and presents a serious clinical and societal problem. A wealth of literature suggests that disruption of sensory processing within the spinal cord contributes to chronic pain, but our limited understanding of spinal circuitry in health and disease remains a barrier to the development of new therapeutic strategies. The aim of this brief review is to outline current thinking about how individual components of functionally-distinct spinal microcircuits can be identified and manipulated to determine their role in influencing our perception of pain in acute and chronic states.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hughes, Dr David I
Authors: Graham, B. A., and Hughes, D. I.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Current Opinion in Physiology
ISSN (Online):2468-8673
Published Online:22 April 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Current Opinion in Physiology 11: 35-41
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
571071Modulating cutaneous afferent input: Identifying a source of presynaptic (axo-axonic) inputs in the mouse spinal dorsal hornDavid I HughesBiotechnology and Biological Sciences Research Council (BBSRC)BB/J000620/1RI NEUROSCIENCE & PSYCHOLOGY
737031Determining the role of calretinin-RorB spinal interneurons in modulating mechanical painDavid I HughesBiotechnology and Biological Sciences Research Council (BBSRC)BB/P007996/1INP - CENTRE FOR NEUROSCIENCE