Tunable supramolecular gels by varying thermal history

Debnath, S. et al. (2019) Tunable supramolecular gels by varying thermal history. Chemistry: A European Journal, 25(33), pp. 7881-7887. (doi: 10.1002/chem.201806281) (PMID:30945773)

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Abstract

The balance between hydrogen bonding and hydrophobic interactions dictates nanofiber obtained by self‐assembly of many low molecular weight gelators. In here, we demonstrate that thermal history can be used as a simple route of controlling structure and function in supramolecular gels. Using a model aromatic peptide amphiphile, Fmoc‐tyrosyl‐leucine and a combination of fluorescence, FTIR, CD and NMR spectroscopy, we show that the balance of these interactions can be adjusted by varying thermal history followed by supramolecular locking in the gel state. Depending on the thermal history that the gelators are exposed to, three regimes can be identified regarding the balance between H‐bonding and aromatic stacking interactions, resulting in different modes of supramolecular packing. Consequently, non‐equilibrium gels can be obtained with customizable properties, including supramolecular chirality, gel stiffness and proteolytic stability, highlighting the possibility of obtaining a range of supramolecular architectures from a single molecular structure.

Item Type:Articles
Additional Information:The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/EMERgE/ERC Grant Agreement No. (258775). (U.K.) We are grateful for financial support from the University of East Anglia through fully funded Ph.D. studentship for SMR.
Keywords:General chemistry.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kelly, Dr Sharon and Abul-Haija, Yousef
Authors: Debnath, S., Roy, S., Abul-Haija, Y. M., Frederix, P. W.J.M., Ramalhete, S. M., Hirst, A. R., Javid, N., Hunt, N. T., Kelly, S. M., Angulo, J., Khimyak, Y. Z., and Ulijn, R. V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Chemistry
Journal Name:Chemistry: A European Journal
Publisher:Wiley
ISSN:0947-6539
ISSN (Online):1521-3765
Published Online:04 April 2019
Copyright Holders:Copyright © 2019 Wiley‐VCH Verlag GmbH and Co. KGaA, Weinheim
First Published:First published in Chemistry: A European Journal 25(33):7881-7887
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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