Urinary biomarkers for renal tract malformations

Magalhães, P., Schanstra, J. P., Carrick, E., Mischak, H. and Zürbig, P. (2016) Urinary biomarkers for renal tract malformations. Expert Review of Proteomics, 13(12), pp. 1121-1129. (doi: 10.1080/14789450.2016.1254555) (PMID:27791437)

Abstract

Introduction: Renal tract malformations (RTMs) are congenital anomalies of the kidneys and urinary tract, which are the major cause of end-stage renal disease in children. Using immunoassay-based approaches (ELISA, western blot), individual urinary proteins including transforming growth factor β, tumor necrosis factor and monocyte attractant proteins 1 were found to be associated to RTMs. However, only mass spectrometry (MS) based methods leading to the identification of panels of protein-based markers composed of fragments of the extracellular matrix allowed the prediction of progression of RTMs and its complications. Areas covered: In this review, we summarized relevant studies identified in “Pubmed” using the keywords “urinary biomarkers” and “proteomics” and “renal tract malformations” or “hydronephrosis” or “ureteropelvic junction obstruction” or “posterior urethral valves” or “vesicoureteral reflux”. These publications represent studies on potential protein-based biomarkers, either individually or combined in panels, of RTMs in human and animal models. Expert commentary: Successful use in the clinic of these protein-based biomarkers will need to involve larger scale studies to reach sufficient power. Improved performance will potentially come from combining immunoassay- and MS-based markers.

• Item Type: Articles
• Additional Information: H. Mischak., J.P. Schanstra and P. Zürbig were supported in part by the European Commission Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 608332 (iMODECKD) and grant agreement no. 305608 (EURenOmics). Furthermore, P. Magalhães received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement no. 642937 (RENALTRACT).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mischak, Professor Harald and Carrick, Dr Emma
• Authors: Magalhães, P., Schanstra, J. P., Carrick, E., Mischak, H., and Zürbig, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Science and Engineering > School of Chemistry
• Journal Name: Expert Review of Proteomics
• Publisher: Taylor & Francis
• ISSN: 1478-9450
• ISSN (Online): 1744-8387
• Published Online: 28 October 2016
• Copyright Holders: Copyright © 2016 Informa UK Limited, trading as Taylor and Francis Group
• First Published: First published in Expert Review of Proteomics 13(12):1121-1129
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher