Mastana, S., Gilmour, A., Ghelani, A., Smith, H. and Samanta, A. (2007) Association of PTPN22 with rheumatoid arthritis among South Asians in the UK. Journal of Rheumatology, 34(10), pp. 1984-1986. (PMID:17696275)
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Publisher's URL: http://www.jrheum.org/content/34/10/1984
Abstract
Objective: To compare the distribution and assess genetic associations of the PTPN22 R620W single-nucleotide polymorphism among South Asian (Asiatic Indian) patients with rheumatoid arthritis (RA) and ethnically matched controls. Methods: DNA samples from 133 rheumatoid factor-positive South Asian RA patients and 149 control subjects from the East Midlands of the UK were genotyped for PTPN22 R620W polymorphism. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results: The PTPN22 *T allele frequency was lower than in the Caucasian populations, but the disease association was significant (odds ratio 5.87, 95% confidence interval 1.68-20.52). Similar association was observed for genotypes containing *T allele. Conclusion: Our results suggest that the T variant acts as a susceptibility allele for autoantibody-positive RA among South Asians.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gilmour, Miss Ashley |
| Authors: | Mastana, S., Gilmour, A., Ghelani, A., Smith, H., and Samanta, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Rheumatology |
| Publisher: | Journal of Rheumatology |
| ISSN: | 0315-162X |
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