Ellaway, A. , Dundas, R. , Robertson, T. and Shiels, P. G. (2019) More miles on the clock: neighbourhood stressors are associated with telomere length in a longitudinal study. PLoS ONE, 14(3), e0214380. (doi: 10.1371/journal.pone.0214380) (PMID:30921393) (PMCID:PMC6438484)
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Abstract
Background: There is a substantial gap in health and longevity between more affluent and more deprived areas, and more knowledge of the determinants of this health divide is required. Experience of the local residential environment is important for health although few studies have examined this in relation to biological markers of age such as telomere length. We sought to examine if residents’ perceptions of neighbourhood stressors over time were associated with telomere length in a community study. Methodology/Principal findings: In a prospective cohort study of 2186 adults in the West of Scotland, we measured neighbourhood stressors at three time points over a 12-year period and telomere length at the end of the study. Using linear regression models, we found that a higher accumulation of neighbourhood stressors over time was associated with shorter telomere length, even after taking cohort, social class, health behaviours (smoking status, diet, physical activity), BMI and depression into account among females only (Beta = 0.007; 95%CI [0.001, 0.012]; P<0.014). Conclusions/Significance: Neighborhood environments are potentially modifiable, and future efforts directed towards improving deleterious local environments may be useful to lessen telomere attrition.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ellaway, Dr Anne and Shiels, Professor Paul and Dundas, Professor Ruth |
| Creator Roles: | Ellaway, A.Conceptualization, Formal analysis, Methodology, Writing – original draft Dundas, R.Formal analysis, Methodology, Writing – review and editing Shiels, P. G.Conceptualization, Formal analysis, Methodology, Writing – review and editing |
| Authors: | Ellaway, A., Dundas, R., Robertson, T., and Shiels, P. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
| Journal Name: | PLoS ONE |
| Publisher: | Public Library of Science |
| ISSN: | 1932-6203 |
| ISSN (Online): | 1932-6203 |
| Copyright Holders: | Copyright © 2019 Ellaway et al. |
| First Published: | First published in PLoS ONE 14(3): e0214380 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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