Lang, N. N. , Guðmundsdóttir, I. J. and Newby, D. E. (2011) Vascular PAR-1: activity and antagonism. Cardiovascular Therapeutics, 29(6), pp. 349-361. (doi: 10.1111/j.1755-5922.2010.00140.x) (PMID:20528879)
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Abstract
Despite major advances in antiplatelet therapies, recurrent cardiovascular events remain high after acute coronary syndrome. Furthermore, incremental benefits achieved in the reduction of atherothrombotic events have almost always been at the expense of hemorrhagic side effects. Thrombin is the most potent platelet activating factor known and it makes important interactions with the endothelium and vascular smooth muscle with proinflammatory, proatherogenic effects. Distinct from its activity within the coagulation cascade, thrombin mediates these effects via protease‐activated receptor type 1 (PAR‐1) in man. This review discusses the role of PAR‐1 in the vasculature and the development of novel PAR‐1 antagonists. These drugs may provide important antiatherothrombotic effects without attendant bleeding complications and could represent a major breakthrough for the treatment of cardiovascular diseases.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Newby, Professor David and Lang, Professor Ninian |
| Authors: | Lang, N. N., Guðmundsdóttir, I. J., and Newby, D. E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Cardiovascular Therapeutics |
| Publisher: | Wiley |
| ISSN: | 1755-5914 |
| ISSN (Online): | 1755-5922 |
| Published Online: | 25 November 2011 |
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