Fulton, B. et al. (2020) ATLANTIS: a randomised multi-arm phase II biomarker-directed umbrella screening trial of maintenance targeted therapy after chemotherapy in patients with advanced or metastatic urothelial cancer. Trials, 21, 344. (doi: 10.1186/s13063-020-04283-5) (PMID:32306987) (PMCID:PMC7168999)
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Abstract
Background: Metastatic urothelial cancer (UC) is the eighth most common cause of cancer death in the UK. Standard first-line treatment, for most patients, is cytotoxic chemotherapy. Although UC is initially sensitive to chemotherapy, relapse is almost inevitable and outcomes are poor; median overall survival is 8 months. Therefore, there is an urgent need for novel therapies to improve outcomes for this patient group. Methods: ATLANTIS is a randomised phase II umbrella-design screening trial of maintenance therapy in biomarker-defined subgroups of patients with advanced UC. The primary end point is progression-free survival, and the study involves over 30 UK cancer centres. Discussion: ATLANTIS is the first study in the UK to employ a precision-medicine approach to patients with UC for maintenance treatment. Agents with a positive efficacy signal will proceed to randomised phase III trials to confirm the activity of novel, biologically stratified therapies in UC. Registration: ATLANTIS trial EudraCT number 2015–003249-25. ISRCTN25859465.
Item Type: | Articles |
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Additional Information: | ATLANTIS is jointly funded by Cancer Research UK, Exelixis Inc, Clovis Oncology and Astellas Europe Ltd. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Fulton, Ben and Morris, Miss Anna and Jones, Professor Robert and Soulis, Mrs Eileen |
Authors: | Fulton, B., Jones, R., Powles, T., Crabb, S., Paul, J., Birtle, A., Chowdhury, S., Hussain, S., Morris, A., Soulis, E., and Morrison, P. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Trials |
Publisher: | Springer |
ISSN: | 1745-6215 |
ISSN (Online): | 1745-6215 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in Trials 21: 344 |
Publisher Policy: | Reproduced under a Creative Commons License |
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