Does sex modify the effect of endovascular treatment for ischemic stroke? A subgroup analysis of seven randomized trials

Chalos, V. et al. (2019) Does sex modify the effect of endovascular treatment for ischemic stroke? A subgroup analysis of seven randomized trials. Stroke, 50(9), pp. 2413-2419. (doi: 10.1161/STROKEAHA.118.023743) (PMID:31412753)

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Background and Purpose: Previous studies have reported less favorable outcome and less effect of endovascular treatment (EVT) after ischemic stroke in women than in men. Our aim was to study the influence of sex on outcome and on the effect of EVT for ischemic stroke in recent randomized trials on EVT. Methods: We used data from 7 randomized controlled trials on EVT within the HERMES collaboration. The primary outcome was 90-day functional outcome (modified Rankin Scale). We compared baseline characteristics and outcomes between men and women. With ordinal logistic regression, we evaluated the association between EVT and 90-day functional outcome for men and women separately, adjusted for potential confounders. We tested for interaction between sex and EVT. Results: We included 1762 patients in the analyses, of whom 833 (47%) were women. Women were older (median, 70 versus 66 years; P<0.001), were smoking less often (30% versus 44%; P<0.001), and had higher collateral grades (grade 3: 46% versus 35%; P<0.001) than men. Functional independence (modified Rankin Scale score, 0–2) at 90 days was reached by 318 women (39%) and 364 men (39%). The effect of EVT on the ordinal modified Rankin Scale was similar in women (adjusted common odds ratio [acOR], 2.13; 95% CI, 1.47–3.07) and men (acOR, 2.16; 95% CI, 1.59–2.96), with a P for interaction of 0.926. Conclusions: Sex does not influence clinical outcome after EVT and does not modify treatment effect of EVT. Therefore, sex should not be a consideration in the selection of patients for EVT.

Item Type:Articles
Additional Information:Sources of Funding: The University of Calgary received an unrestricted grant from Medtronic for the HERMES collaboration (Highly Effective Reperfusion Using Multiple Endovascular Devices) initiative.
Glasgow Author(s) Enlighten ID:Muir, Professor Keith
Authors: Chalos, V., de Ridder, I. R., Lingsma, H., Brown, S., van Oostenbruggge, R. J., Goyal, M., Campbell, B. C.V., Muir, K. W., Guillemin, F., Bracard, S., White, P., Dávalos, A., Jovin, T. G., Hill, M. D., Mitchell, P. J., Demchuck, A. M., Saver, J. L., van Zwam, W. H., and Dippel, D. W.J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Stroke
Publisher:American Heart Association
ISSN (Online):1524-4628
Published Online:15 August 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Stroke 50(9):2413-21493
Publisher Policy:Reproduced under a Creative Commons license

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