Central mineralocorticoid receptors, sympathetic activity, and hypertension

McManus, F., MacKenzie, S.M. and Freel, E.M. (2009) Central mineralocorticoid receptors, sympathetic activity, and hypertension. Current Hypertension Reports, 11(3), pp. 224-230. (doi: 10.1007/s11906-009-0039-0)

Abstract

Recent evidence highlighting the presence of corticosteroid receptors in the central nervous system has prompted further investigation regarding their role in the pathogenesis of hypertension. The sympathetic nervous system, an important factor in the pathogenesis of hypertension, is influenced by sodium and volume status. Activation of central nervous system mineralocorticoid receptors is known to affect sympathetic activity, although the processes that underpin this phenomenon are incompletely understood. This article reviews some of the recent advances in this area, particularly mechanisms by which the mineralocorticoid receptor maintains selectivity for its ligand within the central nervous system, its role in salt appetite, and the possibility of local production of corticosteroids. In addition, the links between central mineralocorticoid receptor activation, stress, sympathetic activity, and hypertension are discussed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McManus, Dr Frances and Freel, Dr Marie and MacKenzie, Dr Scott
• Authors: McManus, F., MacKenzie, S.M., and Freel, E.M.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Hypertension Reports
• ISSN: 1522-6417
• ISSN (Online): 1534-3111