TAM receptors in cardiovascular disease

McShane, L. , Tabas, I., Lemke, G., Kurowska-Stolarska, M. and Maffia, P. (2019) TAM receptors in cardiovascular disease. Cardiovascular Research, 115(5), pp. 1286-1295. (doi: 10.1093/cvr/cvz100) (PMID:30980657) (PMCID:PMC6587925)

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The TAM receptors are a distinct family of three receptor tyrosine kinases, namely Tyro3, Axl, and MerTK. Since their discovery in the early 1990s, they have been studied for their ability to influence numerous diseases, including cancer, chronic inflammatory and autoimmune disorders, and cardiovascular diseases. The TAM receptors demonstrate an ability to influence multiple aspects of cardiovascular pathology via their diverse effects on cells of both the vasculature and the immune system. In this review, we will explore the various functions of the TAM receptors and how they influence cardiovascular disease through regulation of vascular remodelling, efferocytosis and inflammation. Based on this information, we will suggest areas in which further research is required and identify potential targets for therapeutic intervention.

Item Type:Articles
Additional Information:The following UoG grants have been acknowledged: the British Heart Foundation grants [PG/12/81/29897 to PM, RE/13/5/30177 and FS/16/55/32731]; the Engineering and Physical Sciences Research Council (EPSRC) grant [EP/L014165/1 to PM]; the European CommissionMarie Skłodowska-Curie Individual Fellowships [661369 to PM]; the Arthritis Research UK [RACE20298) to MKS]; and National Institutes of Health grants [HL075662, HL127464, and HL132412 to IT].
Glasgow Author(s) Enlighten ID:McShane, Ms Lucy and Maffia, Professor Pasquale and Kurowska-Stolarska, Professor Mariola
Authors: McShane, L., Tabas, I., Lemke, G., Kurowska-Stolarska, M., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Cardiovascular Research
Publisher:Oxford University Press
ISSN (Online):1755-3245
Published Online:13 April 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Cardiovascular Research 115(5):1286-1295
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
614711Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.Pasquale MaffiaBritish Heart Foundation (BHF)PG/12/81/29897III -IMMUNOLOGY
617771BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177RI CARDIOVASCULAR & MEDICAL SCIENCES
644661In Situ Nanoparticle Assemblies for Healthcare Diagnostics and TherapyPasquale MaffiaEngineering and Physical Sciences Research Council (EPSRC)EP/L014165/1III -IMMUNOLOGY
682541NanoMATePasquale MaffiaEuropean Commission (EC)661369III -IMMUNOLOGY