Regulation of Myc by miR-34c: a mechanism to prevent genomic instability?

Cannell, I. and Bushell, M. (2010) Regulation of Myc by miR-34c: a mechanism to prevent genomic instability? Cell Cycle, 9(14), pp. 2798-2802. (doi: 10.4161/cc.9.14.12182) (PMID:20603603)

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Over the past 8 years several lines of compelling evidence have indicated that microRNAs are critical downstream effectors of classic oncogene/tumour suppressor networks. The archetypal examples of oncogene and tumour suppressor microRNAs are the miR-17-92 (oncomir 1) polycistron and miR-34 respectively. Whilst the involvement of these two opposing families of microRNAs in oncogenesis has been known for some time, the mRNA targets through which they exert their phenotypes are only just beginning to be uncovered. Moreover, several recent reports have demonstrated that the relevant physiological targets of certain individual microRNAs are actually fairly limited, with repression of just one or two major targets sufficient to explain the observed phenotype. In this review we will discuss the emerging role of microRNAs in tumourigenesis with a specific focus on miR-34c-dependent regulation of Myc.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bushell, Professor Martin
Authors: Cannell, I., and Bushell, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cell Cycle
Publisher:Taylor & Francis
ISSN (Online):1551-4005
Copyright Holders:Copyright © 2010 Landes Bioscience
First Published:First published in Cell Cycle 9:2798-2802
Publisher Policy:Reproduced under a creative commons licence

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