Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer's disease.

Spiers, J. G., Chen, H.-J. C., Bourgognon, J.-M. and Steinert, J. R. (2019) Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer's disease. Free Radical Biology and Medicine, 134, pp. 468-483. (doi: 10.1016/j.freeradbiomed.2019.01.025) (PMID:30716433)

Abstract

Stress is a multimodal response involving the coordination of numerous body systems in order to maximize the chance of survival. However, long term activation of the stress response results in neuronal oxidative stress via reactive oxygen and nitrogen species generation, contributing to the development of depression. Stress-induced depression shares a high comorbidity with other neurological conditions including Alzheimer's disease (AD) and dementia, often appearing as one of the earliest observable symptoms in these diseases. Furthermore, stress and/or depression appear to exacerbate cognitive impairment in the context of AD associated with dysfunctional catecholaminergic signaling. Given there are a number of homologous pathways involved in the pathophysiology of depression and AD, this article will highlight the mechanisms by which stress-induced perturbations in oxidative stress, and particularly NO signaling, contribute to neurodegeneration. [Abstract copyright: Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.]

• Item Type: Articles
• Additional Information: JRS was funded by a Medical Research Council grant (UK).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bourgognon, Dr Julie-Myrtille
• Authors: Spiers, J. G., Chen, H.-J. C., Bourgognon, J.-M., and Steinert, J. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
• Journal Name: Free Radical Biology and Medicine
• Publisher: Elsevier
• ISSN: 0891-5849
• ISSN (Online): 1873-4596
• Published Online: 02 February 2019