Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s

McCormack, G. P., Glynn, J. R., Crampin, A. C. , Sibande, F., Mulawa, D., Fine, P. E.M. and Clewley, J. P. (2004) Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s. AIDS Research and Human Retroviruses, 19(5), pp. 441-445. (doi: 10.1089/088922203765551782) (PMID:12816092)

Abstract

Six divergent HIV-1 partial env and gag genome sequences have been characterized in five subjects in Malawi, from whom blood spot samples were collected between 1982 and 1989, at the time that the AIDS epidemic there was starting. These sequences could not be classified with any of the recognized subtypes or circulating recombinant forms of HIV-1. They showed no consistent and/or supported associations with other subtypes by either env or gag gene phylogenetic analysis. Their genetic distances from defined subtypes suggest that they may be diverse subsubtype C viruses or, alternatively, that they may have mosaic genomes. Bootscanning analyses are consistent with their being mosaic viruses. These sequences highlight early HIV-1 diversity in a population otherwise dominated by subtype C.

• Item Type: Articles
• Additional Information: Until 1996 the Karonga Prevention Study was funded primarily by LEPRA (the British Leprosy Relief Association) and ILEP (the International Federation of Anti-Leprosy Organizations) with contributions from the WHO/UNDP/World Bank Special Programme for Research and Training in Tropical Dis- eases. Since 1996 the Wellcome Trust has been the principal funder, and funded this study. J.R.G. was supported in part by the British Department for International Development.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crampin, Professor Mia
• Authors: McCormack, G. P., Glynn, J. R., Crampin, A. C., Sibande, F., Mulawa, D., Fine, P. E.M., and Clewley, J. P.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: AIDS Research and Human Retroviruses
• Publisher: Mary Ann Liebert
• ISSN: 0889-2229
• ISSN (Online): 1931-8405