Weir, R. E. et al. (2004) Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 responses compared to those of adolescents in the United Kingdom. Infection and Immunity, 72(3), pp. 1807-1811. (doi: 10.1128/iai.72.3.1807-1811.2004) (PMID:14977992) (PMCID:PMC356017)
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Abstract
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1β (IL-1β), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.
| Item Type: | Articles |
|---|---|
| Additional Information: | The work in Malawi was supported by The Wellcome Trust and that in the United Kingdom was supported by the British Leprosy Relief Association (LEPRA). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Crampin, Professor Mia |
| Authors: | Weir, R. E., Black, G. F., Dockrell, H. M., Floyd, S., Fine, P. E.M., Chaguluka, S. D., Stenson, S., King, E., Nazareth, B., Warndorff, D. K., Ngwira, B., Crampin, A. C., Mwaungulu, L., Sichali, L., Jarman, E., Donovan, L., and Blackwell, J. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
| Journal Name: | Infection and Immunity |
| Publisher: | American Society for Microbiology |
| ISSN: | 0019-9567 |
| ISSN (Online): | 1098-5522 |
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