Tardito, S. , Chiu, M., Franchi-Gazzola, R., Dall’Asta, V., Comi, P. and Bussolati, O. (2012) The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR. Amino Acids, 42(6), pp. 2507-2512. (doi: 10.1007/s00726-011-0981-4) (PMID:21769496)
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Abstract
l-Methionine sulfoximine (MSO) and dl-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the mTOR substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where mTOR activity is very low, but is detectable for PPT also in the presence of glutamine. The stimulation of mTOR activity by either MSO or PPT is strongly synergized by essential amino acids. Thus, the non-proteinogenic amino acids MSO and PPT are mTOR activators.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Tardito, Dr Saverio |
| Authors: | Tardito, S., Chiu, M., Franchi-Gazzola, R., Dall’Asta, V., Comi, P., and Bussolati, O. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Amino Acids |
| Publisher: | Springer |
| ISSN: | 0939-4451 |
| ISSN (Online): | 1438-2199 |
| Published Online: | 17 July 2011 |
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