Houslay, K.F., Fertig, B.A., Christian, F., Tibbo, A.J., Ling, J., Findlay, J.E., Houslay, M.D. and Baillie, G.S. (2019) Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling. Journal of Biochemistry, 166(1), pp. 97-106. (doi: 10.1093/jb/mvz016) (PMID:30859186) (PMCID:PMC6607969)
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Abstract
Phosphodiesterases (PDEs) shape local cAMP gradients to underpin the specificity of receptor function. Key to this process is the highly defined nature of the intra-cellular location of PDEs in the cell. PDE4A5 is a PDE isoform that specifically degrades cAMP and is known to associate with the p75 neurotrophin receptor (p75NTR) where it modulates cAMP signalling cascades that regulate extracellular matrix remodelling in the lungs. Here we map and validate novel protein–protein interaction sites that are important for formation of the PDE4A5–p75NTR complex and show, for the first time, that phosphorylation of PDE4A5 by MAPKAPK2 enhances PDE4A5 interaction with p75NTR and that this, in turn, serves to attenuate fibrin degradation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Baillie, Professor George |
| Authors: | Houslay, K.F., Fertig, B.A., Christian, F., Tibbo, A.J., Ling, J., Findlay, J.E., Houslay, M.D., and Baillie, G.S. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Biochemistry |
| Publisher: | Oxford University Press |
| ISSN: | 0021-924X |
| ISSN (Online): | 1756-2651 |
| Published Online: | 11 March 2019 |
| Copyright Holders: | Copyright © 2019 The Authors |
| First Published: | First published in Journal of Biochemistry 166(1):97-106 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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