Houben, R. M.G.J., Crampin, A. C. , Mallard, K., Mwaungulu, J. N., Yates, M. D., Mwaungulu, F. D., Ngwira, B. M.M., French, N., Fine, P. E.M. and Glynn, J. R. (2009) HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(12), pp. 1187-1189. (doi: 10.1016/j.trstmh.2009.03.013) (PMID:19362727) (PMCID:PMC2784949)
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Abstract
Tuberculosis (TB) patients with strains common to other recent cases (‘clustering’) suggest recent transmission. HIV status and age may affect proportions clustered. We investigated TB clustering by HIV and age in a population-based study in Malawi. Among 746 patients, HIV infection increased the proportion clustered. Sex-period-adjusted odds ratios for the association of HIV and clustering were 1.26 (95% CI 0.4–4.1) for ages 15–25 years, 1.40 (0.9–2.3) for 25–50 years and 10.44 (2.3–47.9) for >50 years and remained stable over two periods examined. These results suggest that HIV increases the proportion of TB due to recent transmission in the elderly.
Item Type: | Articles |
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Additional Information: | The study was funded by The Wellcome Trust UK and the British Leprosy Relief Association. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Crampin, Professor Mia |
Authors: | Houben, R. M.G.J., Crampin, A. C., Mallard, K., Mwaungulu, J. N., Yates, M. D., Mwaungulu, F. D., Ngwira, B. M.M., French, N., Fine, P. E.M., and Glynn, J. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Transactions of the Royal Society of Tropical Medicine and Hygiene |
Publisher: | Oxford University Press |
ISSN: | 0035-9203 |
ISSN (Online): | 1878-3503 |
Published Online: | 11 April 2009 |
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