Thye, T. et al. (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature Genetics, 42(9), pp. 739-741. (doi: 10.1038/ng.639) (PMID:20694014) (PMCID:PMC4975513)
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Abstract
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 × 10−9, odds ratio = 1.19, 95% CI = 1.13–1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
Item Type: | Articles |
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Additional Information: | Authors, for the African TB Genetics Consortium and the Wellcome Trust Case Control Consortium. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Crampin, Professor Mia |
Authors: | Thye, T., Vannberg, F. O., Wong, S. H., Owusu-Dabo, E., Osei, I., Gyapong, J., Sirugo, G., Sisay-Joof, F., Enimil, A., Chinbuah, M. A., Floyd, S., Warndorff, D. K., Sichali, L., Malema, S., Crampin, A. C., Ngwira, B., Teo, Y. Y., Small, K., Rockett, K., Kwiatkowski, D., Fine, P. E., Hill, P. C., Newport, M., Lienhardt, C., Adegbola, R. A., Corrah, T., Ziegler, A., Morris, A. P., Meyer, C. G., Horstmann, R. D., and Hill, A. V.S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Nature Genetics |
Publisher: | Nature Research |
ISSN: | 1061-4036 |
ISSN (Online): | 1546-1718 |
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