Bone, I., Belton, L., Walker, A. and Darbyshire, J. (2008) Intraventricular pentosan polysulphate in human prion disease: An observational study in the UK. European Journal of Neurology, 15(5), pp. 458-464. (doi: 10.1111/j.1468-1331.2008.02108.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1468-1331.2008.02108.x
Abstract
Background, purpose and methods: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK. Results: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 mu g/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly. Conclusion: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Bone, Professor Ian |
Authors: | Bone, I., Belton, L., Walker, A., and Darbyshire, J. |
College/School: | College of Medical Veterinary and Life Sciences |
Journal Name: | European Journal of Neurology |
ISSN: | 1351-5101 |
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