Pigorini, A. et al. (2015) Bistability breaks-off deterministic responses to intracortical stimulation during non-REM sleep. NeuroImage, 112, pp. 105-113. (doi: 10.1016/j.neuroimage.2015.02.056) (PMID:25747918)
|
Text
179628.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 1MB |
Abstract
During non-rapid eye movement (NREM) sleep (stage N3), when consciousness fades, cortico-cortical interactions are impaired while neurons are still active and reactive. Why is this? We compared cortico-cortical evoked-potentials recorded during wakefulness and NREM by means of time–frequency analysis and phase-locking measures in 8 epileptic patients undergoing intra-cerebral stimulations/recordings for clinical evaluation. We observed that, while during wakefulness electrical stimulation triggers a chain of deterministic phase-locked activations in its cortical targets, during NREM the same input induces a slow wave associated with an OFF-period (suppression of power > 20 Hz), possibly reflecting a neuronal down-state. Crucially, after the OFF-period, cortical activity resumes to wakefulness-like levels, but the deterministic effects of the initial input are lost, as indicated by a sharp drop of phase-locked activity. These findings suggest that the intrinsic tendency of cortical neurons to fall into a down-state after a transient activation (i.e. bistability) prevents the emergence of stable patterns of causal interactions among cortical areas during NREM. Besides sleep, the same basic neurophysiological dynamics may play a role in pathological conditions in which thalamo-cortical information integration and consciousness are impaired in spite of preserved neuronal activity.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Palva, Professor Matias |
Authors: | Pigorini, A., Sarasso, S., Proserpio, P., Szymanski, C., Arnulfo, G., Casarotto, S., Fecchio, M., Rosanova, M., Mariotti, M., Lo Russo, G., Palva, J. M., Nobili, L., and Massimini, M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | NeuroImage |
Publisher: | Elsevier |
ISSN: | 1053-8119 |
ISSN (Online): | 1095-9572 |
Published Online: | 04 March 2015 |
Copyright Holders: | Copyright © 2015 The Authors |
First Published: | First published in NeuroImage 112:105-113 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record