Cell growth effects of Epstein-Barr virus leader protein

Allan, G. J., Inman, G. J. , Parker, B. D., Rowe, D. T. and Farrell, P. J. (1992) Cell growth effects of Epstein-Barr virus leader protein. Journal of General Virology, 73(6), pp. 1547-1551. (doi: 10.1099/0022-1317-73-6-1547) (PMID:1318948)

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B lymphoblastoid cell lines immortalized with P3HR1/633 Epstein—Barr virus (EBV), which has a deletion in the EBV nuclear antigen leader protein (EBNA-LP) gene, were transfected with a vector expressing wild-type EBNA-LP. The EBNA-LP trans-fectants grew out faster under G418 selection than control cells but expression of EBNA-LP made no significant difference to growth rate or saturation density of the resulting established cell lines. When the cells expressing EBNA-LP were allowed to grow to saturation and then diluted in fresh medium they underwent DNA synthesis more rapidly than control cultures.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Inman, Professor Gareth
Authors: Allan, G. J., Inman, G. J., Parker, B. D., Rowe, D. T., and Farrell, P. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Journal of General Virology
Publisher:Microbiology Society
ISSN (Online):1465-2099

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