Frame, M. C. and Inman, G. J. (2008) NCAM Is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation. Developmental Cell, 15(4), pp. 494-496. (doi: 10.1016/j.devcel.2008.09.016) (PMID:18854134)
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Abstract
New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Frame, Prof Margaret and Inman, Professor Gareth |
| Authors: | Frame, M. C., and Inman, G. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Developmental Cell |
| Publisher: | Elsevier |
| ISSN: | 1534-5807 |
| ISSN (Online): | 1878-1551 |
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