Hishida, A. et al. (2018) Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care. Oncology Letters, 17(1), pp. 623-629. (doi: 10.3892/ol.2018.9614) (PMID:30655809) (PMCID:PMC6313183)
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Abstract
Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin ( C-31T, VNTR, C-634G, T-251A, T-819C and A-1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotyping was conducted using a polymerase chain reaction with confronting two-pair primers. Patients with at least one allele demonstrated a significantly better survival (P=0.0275) while those with -634 demonstrated a worse survival (P=0.0024). Multivariate analyses using the Cox proportional hazard model revealed that those with at least one allele, -634 or -1082 had a significantly elevated adjusted hazard ratio of 9.20 (P=0.014), 41.01 (P=0.001) or 6.49 (P=0.046), respectively, compared with those with each homozygous wild-type polymorphism. In addition, the evaluation of weight loss by genotype revealed the potential influence of T-819C genotype (P=0.072). and polymorphisms were associated with the survival of patients with gastrointestinal cancer, suggesting the clinical feasibility of genetic testing in patients with gastrointestinal cancer in palliative care.
| Item Type: | Articles |
|---|---|
| Additional Information: | The present study was supported in part by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology, JSPS KAKENHI Grant Number JP (grant no. 25460745). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McMillan, Professor Donald |
| Authors: | Hishida, A., Okugawa, Y., Morimoto, Y., Shirai, Y., Okamoto, K., Momokita, S., Ogawa, A., Tanaka, K., Nishikawa, R., Toiyama, Y., Inoue, Y., Sakurai, H., Urata, H., Tanaka, M., McMillan, D. C., and Miki, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Oncology Letters |
| Publisher: | Spandidos Publications |
| ISSN: | 1792-1074 |
| ISSN (Online): | 1792-1082 |
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