Switching TGFβ from a tumor suppressor to a tumor promoter

Inman, G. J. (2011) Switching TGFβ from a tumor suppressor to a tumor promoter. Current Opinion in Genetics and Development, 21(1), pp. 93-99. (doi: 10.1016/j.gde.2010.12.004) (PMID:21251810)

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TGFβ acts as a potent tumor suppressor and tumor promoter in a context dependent manner. Tumor suppressive functions include inhibition of cell proliferation, induction of apoptosis and regulation of autophagy. As tumors develop they switch their response to TGFβ and utilise this factor as a potent promoter of cell motility, invasion, metastasis and tumor stem cell maintenance. These multifactorial tumor influencing actions of TGFβ involve regulation of an increasing number of signal transduction pathways employing a diverse range of signaling molecules. Understanding the molecular mechanisms of how tumor cells respond to TGFβ and switch their response to this cytokine during disease progression is vital for both the development and the informed use of potentially powerful TGFβ targeted therapeutics.

Item Type:Articles
Additional Information:Research described in this review was funded by an Association for International Cancer Research fellowship and by Cancer Research UK.
Glasgow Author(s) Enlighten ID:Inman, Professor Gareth
Authors: Inman, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Current Opinion in Genetics and Development
ISSN (Online):1879-0380
Published Online:19 January 2011

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