BA08: an open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract

Griffiths, G. O., Cowan, R. A., Grigor, K. M., Uscinska, B. M., Sydes, M. and Russell, M. (2019) BA08: an open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract. PLoS ONE, 14(1), e0210785. (doi: 10.1371/journal.pone.0210785) (PMID:30650143) (PMCID:PMC6334943)

Abstract

Background: Pure squamous cell carcinoma (SCC) of the urinary tract is rare in the UK and has a poor prognosis compared with transitional cell carcinoma (TCC). Cisplatin based chemotherapy has been shown to be effective in TCC. Methods: Patients with T3-T4, pelvic relapsed, nodal or metastatic SCC of the urinary tract were recruited into an open-label, single-arm, non-randomised, phase 2 trial evaluating the activity and safety of cisplatin, methotrexate and vinblastine (CMV) chemotherapy. CMV was given as three 21-day cycles of methotrexate 30mg/m2 (day 1 & 8), vinblastine 4mg/m2 (day 1 & 8) and cisplatin 100mg/m2 (day 2). Results: 38 patients were recruited. Overall response was 39% (95% CI 24%, 55%)–13% CR and 26% PR. Median OS was 7.8 months (95% CI 3.4, 12.6) with 39% 1-year survival. Toxicity was acceptable. Conclusion: CMV is well tolerated and active in patients with pure SCC of the urinary tract.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Russell, Dr Martin

Creator Roles

Russell, M.: Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft

• Authors: Griffiths, G. O., Cowan, R. A., Grigor, K. M., Uscinska, B. M., Sydes, M., and Russell, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: PLoS ONE
• Publisher: Public Library of Science
• ISSN: 1932-6203
• ISSN (Online): 1932-6203
• Copyright Holders: Copyright © 2019 Griffiths et al.
• First Published: First published in PLoS ONE 14(1): e210785
• Publisher Policy: Reproduced under a Creative Commons License