Spender, L. C. and Inman, G. J. (2011) Inhibition of germinal centre apoptotic programmes by Epstein-Barr Virus. Advances in Hematology, 2011, 829525. (doi: 10.1155/2011/829525) (PMID:22110506) (PMCID:PMC3202104)
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Abstract
To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction. This is a site of B cell differentiation where antibody responses are optimised, and the selection criteria for B cells are stringent. The germinal centre environment is harsh, and the vast majority of B cells here die by apoptosis. Only cells receiving adequate survival signals will differentiate fully to be released into the periphery as long-term memory B cells (the site of persistence). In this review, we detail the apoptotic pathways potentially encountered by EBV-infected B cells during the process of infection, and we describe the functions of those EBV-regulated cellular and viral genes that help promote survival of the host B cell.
Item Type: | Articles |
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Additional Information: | Research performed in our laboratory described in this review was funded by an Association for International Cancer Research Fellowship and by Cancer Research UK. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Spender, Dr Lindsay and Inman, Professor Gareth |
Authors: | Spender, L. C., and Inman, G. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Advances in Hematology |
Publisher: | Hindawi |
ISSN: | 1687-9104 |
ISSN (Online): | 1687-9112 |
Copyright Holders: | Copyright © 2011 L.C. Spender and G.J. Inman |
First Published: | First published in Advances in Hematology 2011:829525 |
Publisher Policy: | Reproduced under a Creative Commons License |
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