Inhibition of germinal centre apoptotic programmes by Epstein-Barr Virus

Spender, L. C. and Inman, G. J. (2011) Inhibition of germinal centre apoptotic programmes by Epstein-Barr Virus. Advances in Hematology, 2011, 829525. (doi: 10.1155/2011/829525) (PMID:22110506) (PMCID:PMC3202104)

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To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction. This is a site of B cell differentiation where antibody responses are optimised, and the selection criteria for B cells are stringent. The germinal centre environment is harsh, and the vast majority of B cells here die by apoptosis. Only cells receiving adequate survival signals will differentiate fully to be released into the periphery as long-term memory B cells (the site of persistence). In this review, we detail the apoptotic pathways potentially encountered by EBV-infected B cells during the process of infection, and we describe the functions of those EBV-regulated cellular and viral genes that help promote survival of the host B cell.

Item Type:Articles
Additional Information:Research performed in our laboratory described in this review was funded by an Association for International Cancer Research Fellowship and by Cancer Research UK.
Glasgow Author(s) Enlighten ID:Spender, Dr Lindsay and Inman, Professor Gareth
Authors: Spender, L. C., and Inman, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Advances in Hematology
ISSN (Online):1687-9112
Copyright Holders:Copyright © 2011 L.C. Spender and G.J. Inman
First Published:First published in Advances in Hematology 2011:829525
Publisher Policy:Reproduced under a Creative Commons License

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