Birth weight and adolescent blood pressure measured at age 12 years in the Gateshead Millennium Study

Mann, K.D., Basterfield, L., Wright, C. , Parkinson, K., Reilly, J.K., Reilly, J.J., Adamson, A.J. and Pearce, M.S. (2019) Birth weight and adolescent blood pressure measured at age 12 years in the Gateshead Millennium Study. Journal of Developmental Origins of Health and Disease, 10(6), pp. 621-626. (doi: 10.1017/S2040174418001095) (PMID:30621799)

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Abstract

Birth weight and early growth have been associated with later blood pressure. However, not all studies consistently find a significant reduction in blood pressure with an increase in birth weight. In addition, the relative importance of birth weight and of other lifestyle and environmental factors is often overlooked and the association is rarely studied in adolescents. We investigated early life predictors, including birth weight, of adolescent blood pressure in the Gateshead Millennium Study (GMS). The GMS is a cohort of 1029 individuals born in 1999-2000 in Gateshead in Northern England. Throughout infancy and early childhood, detailed information were collected, including birth weight and measures of height and weight. Assessments of 491 returning participants at age 12 years included measures of body mass and blood pressure. Linear regression and path analysis were used to determine predictors and their relative importance on blood pressure. Birth weight was not directly associated with blood pressure at the age of 12. However, after adjustment for contemporaneous body mass index (BMI), an inverse association of standardized birth weight on systolic blood pressure was significant. The relative importance of birth weight on later systolic blood pressure was smaller than other contemporaneous body measures (height and BMI). There was no independent association of birth weight on blood pressure seen in this adolescent population. Contemporaneous body measures have an important role to play. Lifestyle factors that influence body mass or size, such as diet and physical activity, where interventions are directed at early prevention of hypertension should be targeted.

Item Type:Articles
Additional Information:This work was supported by funding from Breathe North, UK, and the Gateshead Millennium Study was supported by the University of Strathclyde, Gateshead Council and the Mental Health Foundation. Previous funding came from the Scottish Government Chief Scientist Office, the UK National Prevention Research Initiative and Gateshead PCT. The cohort was first established with funding from the Henry Smith Charity and Sport Aiding Research in Kids and followed up with grants from Gateshead NHS Trust R&D, Northern and Yorkshire NHS R&D, and Northumberland, Tyne and Wear NHS Trust.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wright, Professor Charlotte
Authors: Mann, K.D., Basterfield, L., Wright, C., Parkinson, K., Reilly, J.K., Reilly, J.J., Adamson, A.J., and Pearce, M.S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Developmental Origins of Health and Disease
Publisher:Cambridge University Press
ISSN:2040-1744
ISSN (Online):2040-1752
Published Online:09 January 2019
Copyright Holders:Copyright © 2019 Cambridge University Press and the International Society for Developmental Origins of Health and Disease
First Published:First published in Journal of Developmental Origins of Health and Disease 10(6):621-626
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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