The mechanisms of action of gabapentin and pregabalin

Sills, G. J. (2006) The mechanisms of action of gabapentin and pregabalin. Current Opinion in Pharmacology, 6(1), pp. 108-113. (doi: 10.1016/j.coph.2005.11.003) (PMID:16376147)

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Gabapentin and pregabalin are structurally related compounds with recognized efficacy in the treatment of both epilepsy and neuropathic pain. The pharmacological mechanisms by which these agents exert their clinical effects have, until recently, remained unclear. The interaction of gabapentin and pregabalin with conventional antiepileptic and analgesic drug targets is likely to be modest, at best, and has been largely dismissed in favour of a selective inhibitory effect on voltage-gated calcium channels containing the α2δ-1 subunit. This mechanism is consistently observed in both rodent- and human-based experimental paradigms and may be sufficiently robust to account for much of the clinical activity of these compounds.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Sills, Dr Graeme
Authors: Sills, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Current Opinion in Pharmacology
ISSN (Online):1471-4973

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