Investigation of the factors affecting the photothermal therapy potential of small iron oxide nanoparticles over the 730–840 nm spectral region

Bilici, K., Muti, A., Demir Duman, F. , Sennaroglu, A. and Yağcı Acar, H. (2018) Investigation of the factors affecting the photothermal therapy potential of small iron oxide nanoparticles over the 730–840 nm spectral region. Photochemical and Photobiological Sciences, 17(11), pp. 1787-1793. (doi: 10.1039/C8PP00203G) (PMID:30168556)

Abstract

The use of superparamagnetic iron oxide nanoparticles (SPIONs) as a sensitizer in photothermal therapy (PTT) is relatively new and the origin of such a phenomenon is not known. Usually, large crystals and aggregated particles are preferred in the literature, suggesting that these increase the absorbance of particles at the irradiation wavelength, and hence, provide a larger temperature increase. This study has two major goals: identification of the key factors that affect the photo-induced temperature increase in well-controlled experiments and the influence of laser irradiation on nanoparticle properties. Small, biocompatible poly(acrylic acid) coated SPIONs (PAA/SPIONs) were used since they are more practical for future medical use than large aggregates. We studied the impact of three major laser-dependent variables, namely the wavelength (between 728 and 838 nm), intensity (1.85–9.76 W cm−2) and power (105–800 mW) as well as attenuation at the irradiation wavelength, on photothermal heating achieved with PAA/SPIONs. Within the studied range of these variables, only the laser power plays a critical role on the magnitude of photothermal heating in solutions. There is no strong correlation between the attenuation at the excitation wavelength and the temperature increase. In addition, extensive characterization of SPIONs before and after irradiation revealed no significant difference, which supports the re-usability of SPIONs. Lastly, the PTT potential of these small PAA/SPIONs was demonstrated in vitro on HeLa cells. At these low laser powers no temperature increase in SPION-free water or cell death in SPION-free cells was detected. Hence, this study provides a new insight into the photothermal effect of SPIONs, provides a clear and repeatable experimental procedure and demonstrates great potential for small SPIONs to be exploited in PTT.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Demir Duman, Dr Fatma
• Authors: Bilici, K., Muti, A., Demir Duman, F., Sennaroglu, A., and Yağcı Acar, H.
• Subjects: Q Science > QD Chemistry; R Medicine > RM Therapeutics. Pharmacology
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Photochemical and Photobiological Sciences
• Publisher: Royal Society of Chemistry
• ISSN: 1474-905X
• ISSN (Online): 1474-9092
• Published Online: 29 August 2018