Effects of some natural leads on Trypanosoma and Leishmania strains

Alkhaldi, A.A.M., De Koning, H.P. and Bukhari, S.N.A. (2019) Effects of some natural leads on Trypanosoma and Leishmania strains. Tropical Biomedicine, 36(2), pp. 373-378.

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Publisher's URL: http://msptm.org/files/Vol36No2/373-378-Bukhari-SNA.pdf


Well-known medical herbal compounds including apigenin, daidzein, phyllanthin and tyramine were assessed against Trypanosoma and Leishmania protozoans. Two strains of the bloodstream forms of Trypanosoma brucei: s427-WT and TbAT1-B48, and Leishmania major and Leishmania mexicana promastigotes were utilised. Among selected natural compounds, apigenin and daidzein displayed moderate activity against African trypanosomes with EC50 16 µM for wild-type sensitive control strain. Tyramine was not found to be very active for trypanosomes strains while all compounds were found to have trivial activity for the inhibition of Leishmania mexicana strains.

Item Type:Articles
Glasgow Author(s) Enlighten ID:De Koning, Professor Harry
Authors: Alkhaldi, A.A.M., De Koning, H.P., and Bukhari, S.N.A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Tropical Biomedicine
Publisher:Malaysian Society of Parasitology and Tropical Medicine
Copyright Holders:Copyright © 2019 Tropical Biomedicine
First Published:First published in Tropical Biomedicine 36(2): 373-378
Publisher Policy:Reproduced with the permission of the Publisher

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