Development of a person-centered conceptual model of perceived fatigability

Kratz, A. L., Murphy, S. L., Braley, T. J., Basu, N. , Kulkarni, S., Russell, J. and Carlozzi, N. E. (2019) Development of a person-centered conceptual model of perceived fatigability. Quality of Life Research, 28, pp. 1337-1347. (doi: 10.1007/s11136-018-2093-z) (PMID:30604341) (PMCID:PMC7395299)

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Purpose: Perceived fatigability, reflective of changes in fatigue intensity in the context of activity, has emerged as a potentially important clinical outcome and quality of life indicator. Unfortunately, the nature of perceived fatigability is not well characterized. The aim of this study is to define the characteristics of fatigability through the development of a conceptual model informed by input from key stakeholders who experience fatigability, including the general population, individuals with multiple sclerosis (MS), and individuals with fibromyalgia (FM). Methods: Thirteen focus groups were conducted with 101 participants; five groups with n = 44 individuals representing the general population, four groups with n = 26 individuals with MS, and four groups with n = 31 individuals with FM. Focus group data were qualitatively analyzed to identify major themes in the participants’ characterizations of perceived fatigability. Results: Seven major themes were identified: general fatigability, physical fatigability, mental fatigability, emotional fatigability, moderators of fatigability, proactive and reactive behaviors, and temporal aspects of fatigability. Relative to those in the general sample, FM or MS groups more often described experiencing fatigue as a result of cognitive activity, use of proactive behaviors to manage fatigability, and sensory stimulation as exacerbating fatigability. Conclusions: Fatigability is the complex and dynamic process of the development of physical, mental, and/or emotional fatigue. Trait- and state-like biological, psychological, social, and environmental moderators contribute to tremendous variability in fatigability (both between and within-person variability). Future research to further characterize fatigability across populations, test treatments for fatigability, and develop new measures of this construct are greatly needed.

Item Type:Articles
Additional Information:Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number R21AG053186; PI: Kratz. Dr. Kratz was supported during manuscript preparation by a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (Award Number K01AR064275). The U-M Pepper Center, which is funded by the National Institute of Aging (Award Number AG024824), provided assistance with subject recruitment.
Glasgow Author(s) Enlighten ID:Basu, Professor Neil
Authors: Kratz, A. L., Murphy, S. L., Braley, T. J., Basu, N., Kulkarni, S., Russell, J., and Carlozzi, N. E.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Quality of Life Research
ISSN (Online):1573-2649
Copyright Holders:Copyright © Springer Nature Switzerland AG 2019
First Published:First published in Quality of Life Research 28:1337-1347
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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