Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18(18), pp. 4940-4943. (doi: 10.1016/j.bmcl.2008.08.041)
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Abstract
A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Dewar, Dr Deborah and Pimlott, Dr Sally and Sutherland, Professor Andrew |
Authors: | Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience College of Science and Engineering > School of Chemistry |
Journal Name: | Bioorganic and Medicinal Chemistry Letters |
ISSN: | 0960-894X |
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