Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?

Walker, L. and Sills, G. J. (2012) Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy? Epilepsy Currents, 12(1), pp. 8-12. (doi:10.5698/1535-7511-12.1.8) (PMID:22368518) (PMCID:PMC3280476)

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Abstract

Emerging data from experimental epilepsy models and resected human brain tissue support the proposed involvement of innate immune system activation and consequent inflammation in epilepsy. Key mediators of this process include interleukin-1β, high-mobility group box protein 1 (HMGB1), and Toll-like receptor (TLR) signaling. These recent findings constitute the basis for a novel avenue of drug development in epilepsy, one that is not only distinct from previous approaches but uniquely based on sound neurobiological evidence.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sills, Dr Graeme
Authors: Walker, L., and Sills, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Epilepsy Currents
Publisher:SAGE
ISSN:1535-7597
ISSN (Online):1535-7511

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