Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study

Kwan, P., Sills, G. J., Kelly, K., Butler, E. and Brodie, M. J. (2000) Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Research, 42(2-3), pp. 191-195. (doi:10.1016/S0920-1211(00)00180-7) (PMID:11074191)

Full text not currently available from Enlighten.

Abstract

There have been anecdotal reports of raised glutamic acid decarboxylase (GAD) autoantibodies in patients with refractory epilepsy. We measured serum GAD autoantibodies in 105 patients with idiopathic or symptomatic epilepsy. There was no significant difference in the absolute titre of GAD autoantibody between patients with controlled and uncontrolled epilepsy. However, four female patients with uncontrolled epilepsy had levels that were over three times above the highest detected in the seizure-free group, three of whom also tested positive for pancreatic islet cell antibodies. Larger scale studies, perhaps comparing different epilepsy syndromes, are required to determine the exact clinical role of GAD autoantibodies in epilepsy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Brodie, Professor Martin and Butler, Mrs Elaine and Sills, Dr Graeme
Authors: Kwan, P., Sills, G. J., Kelly, K., Butler, E., and Brodie, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Epilepsy Research
Publisher:Elsevier
ISSN:0920-1211
ISSN (Online):1872-6844

University Staff: Request a correction | Enlighten Editors: Update this record