Kwan, P., Sills, G. J., Kelly, K., Butler, E. and Brodie, M. J. (2000) Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Research, 42(2-3), pp. 191-195. (doi: 10.1016/S0920-1211(00)00180-7) (PMID:11074191)
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Abstract
There have been anecdotal reports of raised glutamic acid decarboxylase (GAD) autoantibodies in patients with refractory epilepsy. We measured serum GAD autoantibodies in 105 patients with idiopathic or symptomatic epilepsy. There was no significant difference in the absolute titre of GAD autoantibody between patients with controlled and uncontrolled epilepsy. However, four female patients with uncontrolled epilepsy had levels that were over three times above the highest detected in the seizure-free group, three of whom also tested positive for pancreatic islet cell antibodies. Larger scale studies, perhaps comparing different epilepsy syndromes, are required to determine the exact clinical role of GAD autoantibodies in epilepsy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Brodie, Professor Martin and Butler, Mrs Elaine and Sills, Dr Graeme |
| Authors: | Kwan, P., Sills, G. J., Kelly, K., Butler, E., and Brodie, M. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Life Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Epilepsy Research |
| Publisher: | Elsevier |
| ISSN: | 0920-1211 |
| ISSN (Online): | 1872-6844 |
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