Magri, A., Mokrane, O., Lauder, K., Patel, A. H. and Castagnolo, D. (2019) Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of Hepatitis C Virus. Bioorganic and Medicinal Chemistry Letters, 29(5), pp. 724-728. (doi: 10.1016/j.bmcl.2019.01.008) (PMID:30661824)
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Abstract
Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Patel, Professor Arvind and Magri, Mr Andrea |
Authors: | Magri, A., Mokrane, O., Lauder, K., Patel, A. H., and Castagnolo, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Bioorganic and Medicinal Chemistry Letters |
Publisher: | Elsevier |
ISSN: | 0960-894X |
ISSN (Online): | 1464-3405 |
Published Online: | 11 January 2019 |
Copyright Holders: | Copyright © 2019 The Authors |
First Published: | First published in Bioorganic and Medicinal Chemistry Letters 29(5):724-728 |
Publisher Policy: | Reproduced under a Creative Commons License |
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