Dose-response relationships with nimodipine against electroshock seizures in mice

Sills, G.J., Carswell, A. and Brodie, M.J. (1994) Dose-response relationships with nimodipine against electroshock seizures in mice. Epilepsia, 35(2), pp. 437-442. (doi:10.1111/j.1528-1157.1994.tb02457.x) (PMID:8156970)

Full text not currently available from Enlighten.

Abstract

The anticonvulsant effect of the dihydropyridine calcium channel blocker, nimodipine (NMD) was evaluated against electroshock‐induced seizures in mice. At 1 h postdosing, NMD elicited a dose‐dependent reduction in the occurrence of tonic hindlimb extension (THE) after maximal electroshock (MES). The calculated ED50 for NMD was 87 mg/kg. A single dose of NMD (75 mg/kg) produced a significant (p < 0.05) reduction in occurrence of THE for 12 h postdosing. NMD was detectable for 6 h, and plasma and brain drug concentrations correlated well (r= 0.677, p < 0.01) for that period. At 1 h postdose, a single dose of NMD (75 mg/kg) produced a 40% increase (p < 0.001) in the threshold for tonic seizures as determined by minimal electroshock (Min‐ES). NMD is an effective anticonvulsant against experimental seizures induced by electroshock. The pharmacodynamic effect of NMD appears to extend beyond the time anticipated from the pharmacokinetic profile.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sills, Dr Graeme
Authors: Sills, G.J., Carswell, A., and Brodie, M.J.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Epilepsia
Publisher:Wiley
ISSN:0013-9580
ISSN (Online):1528-1167

University Staff: Request a correction | Enlighten Editors: Update this record