A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy

Thomas, R. H., Walsh, J., Church, C., Sills, G. J., Marson, A. G., Baker, G. A. and Rees, M. I. (2014) A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy. Epilepsy and Behavior, 36, pp. 124-129. (doi:10.1016/j.yebeh.2014.04.027) (PMID:24938758)

Full text not currently available from Enlighten.

Abstract

The study of juvenile myoclonic epilepsy is important in that: it is common and heterogeneous; the etiology is unknown; and patients report broad cognitive problems. We utilized a broad battery of neuropsychometric tests to assess the following: intellectual function, memory, language and naming, executive function, the impact of epilepsy, and antiepilepsy drug side effects. Sixty people with drug-refractory JME were interviewed, and performance was profoundly impaired across the range of tests. Impairments included the following: full-scale IQ (89, p < 0.001); processing speed (86, p < 0.001); visual memory (immediate and delayed) more affected than verbal memory; verbal fluency and inhibition (p < 0.001); and self-reported drug side effects (p < 0.001). Eighty-three percent of patients exhibited frank executive dysfunction, which was moderate to severe in 66%. Regression modeling confirmed that an early age at onset and the need for polytherapy were associated with poorer cognitive outcomes. This study confirms previous reports of executive dysfunction in a larger cohort and with greater statistical rigor. We also identified a high prevalence of neurotoxicity symptoms such as fatigue and poorer functioning across intellectual and memory tests than had previously been reported.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sills, Dr Graeme
Authors: Thomas, R. H., Walsh, J., Church, C., Sills, G. J., Marson, A. G., Baker, G. A., and Rees, M. I.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Epilepsy and Behavior
Publisher:Elsevier
ISSN:1525-5050
ISSN (Online):1525-5069

University Staff: Request a correction | Enlighten Editors: Update this record