A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease

Walker, L. E., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., Antoine, D. J., Solomon, T., Marson, A. G. and Pirmohamed, M. (2017) A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), pp. 635-642. (doi: 10.1080/1354750X.2016.1265003) (PMID:27899037)

Abstract

Aims: To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, high-mobility group box 1 (HMGB1), in different neurological conditions. Methods: HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension [IIH], 18 neurological infection/inflammation [NII] and 10 Rasmussen’s encephalitis [RE]). Results: Mean serum (± SD) HMGB1 levels were 1.43 ± 0.54, 25.28 ± 27.9 and 1.89 ± 1.49 ng/ml for the patients with IIH, NII and RE, respectively. Corresponding mean (± SD) CSF levels were 0.35 ± 0.22, 4.48 ± 6.56 and 2.24 ± 2.35 ng/ml. Both CSF and serum HMGB1 was elevated in NII. Elevated CSF HMGB1 was demonstrated in RE. There was no direct correlation between CSF and serum levels of HMGB1. Conclusion: Serum HMGB1 cannot be used as a surrogate measure for CSF levels. CSF HMGB1 was elevated in NII and RE, its role as a prognostic/stratification biomarker needs further study.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sills, Dr Graeme
• Authors: Walker, L. E., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., Antoine, D. J., Solomon, T., Marson, A. G., and Pirmohamed, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Life Sciences
• Journal Name: Biomarkers
• Publisher: Taylor and Francis
• ISSN: 1354-750X
• ISSN (Online): 1366-5804
• Published Online: 08 December 2016
• Copyright Holders: Copyright © 2016 The Authors
• First Published: First published in Biomarkers 22(7):635-642
• Publisher Policy: Reproduced under a Creative Commons License